Relation of p53 Codon 72 Polymorphism with Breast Cancer Risk in DPR Korea Women

Authors

  • Tae-Yong Jon Institute of Medical Genetics, Pyongyang Medical College, KIM IL SUNG University
  • Hui-Myong Pak Breast Oncology Institute, Pyongyang Maternity Hospital
  • Chong-Won Ri Breast Oncology Institute, Pyongyang Maternity Hospital
  • Chong-Kwon Ri Oncology institute, Academy of Medical Science
  • Un-Rim Sim Pyongyang Medical College, KIM IL SUNG University

Abstract

Background: The p53 codon 72 polymorphism (rs1042522) is a single-nucleotide polymorphism (SNP) in exon 4 of p53 gene, resulting in the expression of either arginine (Arg), which encodes CGC, or proline (Pro), which encodes CCC. The p53 codon 72 polymorphism have been implicated as a risk factor for various cancers including breast cancer. We have investigated the association of the Arg/Pro polymorphism at codon 72 of p53 gene with breast cancer risk in women from DPR Korea. Methods: Tumor tissue samples from 97 women with primary breast carcinoma and radix pili tissue samples from 96 healthy females were collected and then analyzed through polymerase chain reaction (PCR). Results: The proportion of the polymorphic forms of SNP72 in DPR Korea breast cancer patients were Arg/Arg (RR), 17.5%; Pro/Pro (PP), 1.0%; and Arg/Pro (RP), 81.4%. The frequencies of these forms in healthy females were 30.2%, 3.1% and 66.7%, respectively. This indicated that Arg/Pro and Pro/Pro has higher risk of breast cancer than Arg/Arg (Odds ratio=2.0, 95% Confidential Interval=1.0~4.0, P=0.039). But no correlation between the genotype distribution and clinicopathological features of breast cancer was observed. Conclusion: In dominant genetic model of Pro allele, a statistically significant association was found between the p53 codon 72 polymorphism and breast cancer risk. These results suggested that Pro72 allele was associated with higher risk for breast cancer patients. Women with Pro72 allele have increased risk of developing breast cancer.


Keywords: Breast cancer, breast cancer risk, risk factor, p53 codon 72 (Arg72Pro) polymorphism

 

Cite this Article

Tae-Yong Jon, Hui-Myong Pak, Chong-Won Ri, Chong-Kwon Ri, Un-Rim Sim. Relation of p53 Codon 72 Polymorphism with Breast Cancer Risk in DPR Korea Women. Research & Reviews: A Journal of Bioinformatics. 2020; 7(1): 23–30p.

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Published

2020-05-11

Issue

Vol. 7 No. 1 (2020)

Section

Research Article

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