In Silico Study of Curcumin-Sugar Conjugates as Dual Inhibitors on Both COX-1 and COX-2 Enzymes for the Discovery of Anti-inflammatory Agents

Authors

  • Ruchika Goyal Department of Pharmaceutical Sciences, Drug Discovery and Research Laboratory, Guru Jambheshwar University of Science and Technology, Hissar, Haryana, India
  • Sandeep Jain Department of Pharmaceutical Sciences, Drug Discovery and Research Laboratory, Guru Jambheshwar University of Science and Technology, Hissar, Haryana, India

DOI:

https://doi.org/10.37591/(rrjobi).v4i1.411

Abstract

Curcumin is a polyphenolic compound well known for its anti-inflammatory properties. The aim of the study was to design some novel curcumin derivatives that are water soluble as well as good anti-inflammatory agents with fewer side effects. In silico study was performed on the proteins by using three softwares iGEMDOCK, AutoDOCK, AutoDOCKVina as dual inhibitors for both COX-1 and COX-2. The result gives us theoretical contribution for understanding the ligand-protein interactions at molecular level. Furthermore, we could also develop some novel curcumin analogues that possess good anti-inflammatory activity, water solubility and lower toxicity.

 

Keywords: Curcumin, inflammation, docking, COX-1, COX-2

Cite this Article

Ruchika Goyal, Sandeep Jain. In Silico Study of Curcumin-Sugar Conjugates as Dual Inhibitors on Both COX-1 and COX-2 Enzymes for the Discovery of Anti-Inflammatory Agents. Research & Reviews: A Journal of Bioinformatics. 2017; 4(1): 25–30p.

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Published

2019-03-26

Issue

Vol. 4 No. 1 (2017)

Section

Research Article

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