QSAR Analysis on a Series of Triazole Based Tubulin Polymerization Inhibitors

Authors

  • Akanksha .
  • Vikas Mehta
  • Richa Dhingra
  • Neelima Dhingra

DOI:

https://doi.org/10.37591/(rrjobi).v4i2.10

Abstract

Abstract

The polymerization progression of microtubules is vital to their natural capacities. Polymerization flow allows microtubules to embrace spatial courses of action that can change quickly because of cell needs and, at times, to perform mechanical work. Compounds that interfere with the microtubule-tubulin equilibria in cells are helpful in the treatment of human diseases. A few triazoles mimics of combretastatin-benzothiazole (CAB) hybrids had good activity as inhibitors both of tubulin polymerization and of the development of DU-145 human prostate tumor cells. Display work depicts correlation between the tubulin polymerization inhibitory activity for fundamentally related cis-restricted triazole mimics of CAB hybrids and their physicochemical descriptors in quantitative terms. The measurably approved two-dimensional quantitative structure activity relationship (2D QSAR) display has been gotten through numerous multiple linear regression (MLR) examination strategy used Vlife molecular design suits (MDS). Factual information of Model 5 (r2 = 0.9922, q2 =0.7045; F = 147.7612, pred r2 = 0.8025) related with tubulin polymerization inhibitory activity. Model has included and featured the positive and negative correlation of four-five descriptors with the biological activity.

Keywords: Microtubules, tubulin polymerization inhibitors, triazole, regression analysis, QSAR

Cite this Article

Akanksha, Vikas Mehta, Richa Dhingra et al. QSAR Analysis on a Series of Triazole Based Tubulin Polymerization Inhibitors. Research & Reviews: A Journal of Bioinformatics. 2017; 4(2): 5–20p.

Downloads

Published

2019-03-14

Issue

Vol. 4 No. 2 (2017)

Section

Research Article

License

Declaration and Copyright Transfer Form

(to be completed by authors)

I/ We, the undersigned author(s) of the submitted manuscript, hereby declare, that the above manuscript which is submitted for publication in the STM Journals(s), is not published already in part or whole (except in the form of abstract) in any journal or magazine for private or public circulation, and, is not under consideration of publication elsewhere.

  • I/We will not withdraw the manuscript after 1 week of submission as I have read the Author Guidelines and will adhere to the guidelines.
  • I/We Author(s ) have niether given nor will give this manuscript elsewhere for publishing after submitting in STM Journal(s).
  • I/ We have read the original version of the manuscript and am/ are responsible for the thought contents embodied in it. The work dealt in the manuscript is my/ our own, and my/ our individual contribution to this work is significant enough to qualify for authorship.
  •  I/We also agree to the authorship of the article in the following order:

Author’s name                                    

 

1. ________________

2. ________________

3. ________________

4. ________________

 

We  Author(s) tick this box and would request you to consider it as our signature as we agree to the terms of this Copyright Notice, which will apply to this submission if and when it is published by this journal.