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A Benign Route for the Synthesis of MgO Nanoparticles and Their Antifungal Activity

Shazia Parveen, Mohd Yaqub Bhat, Abdul Hamid Wani, Mohammad Ashraf Shah, Henam Sylvia Devi, Jahangir Abdullah Koka


Magnesium oxide nanoparticles (MgO NP’s) with particle size 50±10 nm were prepared by hydrothermal method and further characterized by X-ray Diffractometry (XRD) and high resolution field emission scanning electron microscopy (FESEM). The prepared MgO NP’s were also evaluated for their antifungal activity against Trichothecium roseum, Cladosporium herbarum, and Alternaria alternata. The antifungal activity of the synthesized nanoparticles against the selected fungi was assessed as reduction in spore germination and by measuring the zone of inhibition on culture media. From the present study it was revealed that the synthesized MgO nanoparticles showed significant antifungal activity. Highest reduction in spore germination by MgO NP’s was caused against T. roseum (84.21%) followed by C. herbarum (69.84%). The highest zone of inhibition was reported against by A. alternata (24.67) followed by T. roseum (21.67 mm). Activity index was recorded highest against T. roseum (0.81). The MIC value varies between 0.063–0.250 mg/ml that is comparable with the MIC value shown by the standard, revealing the efficacy of MgO NP’s against different fungal pathogens.


Antifungal activity, FESEM, nanoparticles, XRD, zone of inhibition

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