Open Access Open Access  Restricted Access Subscription or Fee Access

Use of CRISPR/Cas9 in Delivery System with Nanotechnology Concept

Maiolica Bandyopadhyay

Abstract


In this emerging era of science and technology development, the use of drug delivery concept has made possible to cure several health problems, but for certain genetic diseases like Sickle cell anemia, chronic diseases like cancers, Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)/CRISPR associated system (Cas) gene-editing system is here as a promising tool to cure them by doing certain gene manipulation in specific gene area causing the disease. However, significant challenges are still in hold in clinical and therapeutic applications to be fulfilled by this CRISPR technology. The safety and efficiency of delivery to target sites in vivo are the major challenges for it, and to solve these, nanotechnology is a new but a great concept which contributed towards many therapeutic applications by certain nanocarriers like in Cancer drug delivery. Due to the small size of different nanoparticles, they are becoming a major vehicle to carry and transfer certain drugs towards target site in safe and efficient way. This review will discuss in brief, how nanotechnology field made a huge impact in drug delivery system using CRISPR/Cas9 system and how interdisciplinary are these three domains in medical field with benefits and positive outcomes to society.


Keywords


Nanotechnology, drug delivery, CRISPR-Cas9, nanoparticles, nanocarriers, nanomaterial

Full Text:

PDF

References


Yaqoob, Asim Ali, et al. Recent advances in metal decorated nanomaterials and their various biological applications: a review. Front Chem. 2020; 8: 341.

Drug Delivery Systems. Nih.gov., 2022. Accessed August 17, 2022. https://www.nibib.nih.gov/science-education/science-topics/drug-delivery-systems-getting-drugs-their-targets-controlled-

manner

Akçaa B, Canab M, DeğirmenciaA V, Yilmazc D. Ünera. Science and Technology in Catalysis, Mesoporous Material-an overview. 2006. [online Available] https://www.sciencedirect.com/topics/materials-science/mesoporous-material

Carbon Nanotubes-Insightsias. Insightsias. Published September 10, 2021. Accessed August 17, 2022. https://www.insightsonindia.com/sciencetechnology/nanotechnology/carbon-nanotubes/

Dinda C, Subas, Gurudutta Pattnaik. Nanobiotechnology-based drug delivery in brain targeting. Curr Pharm Biotechnol. 2013; 14(1): 1264–1274.

Yafout Mohamed, et al. Gold nanoparticles as a drug delivery system for standard chemotherapeutics: A new lead for targeted pharmacological cancer treatments. Sci Afr. 2021; 11: e00685.

Gibney M. Radiated gold nanoparticles target cancer cell division. Fierce Biotech. Published November 9, 2016. Accessed August 17, 2022. https://www.fiercebiotech.com/research/radiated- gold-nanoparticles-target-cancer-cell-division

Schwab J. Drugs, Health & Behavior. Unizin.org. Published August 20, 2018. Accessed August 17, 2022. https://psu.pb.unizin.org/bbh143/

Drug Delivery Methods. Utah.edu. Published 2013. Accessed August 17, 2022. https://learn.genetics.utah.edu/content/addiction/delivery/

Dinda SC, Gurudutta Pattnaik. Nanobiotechnology-based Drug Delivery in Brain Targeting. Curr Pharm Biotechnol. 2022; 14(15): 1264–1274. Accessed August 17, 2022. http://www.eurekaselect.com/article/60875

Xu Xiaoyu, et al. Nanotechnology-based delivery of CRISPR/Cas9 for cancer treatment. Adv Drug Deliv Rev. 2021; 176: 113891.

Patra Jayanta Kumar, et al. Nano based drug delivery systems: recent developments and future prospects. J Nanobiotechnol. 2018; 16(1): 1–33.

Duan Li, et al. Nanoparticle delivery of CRISPR/Cas9 for genome editing. Front Genet. 2021; 12: 673286.

Chen J. Noble Metal Nanoparticle Platform. Cancer Theranostics. Published online 2014: 327–346. doi:10.1016/b978-0-12-407722-5.00018-9

Gowda Raghavendra, et al. Use of nanotechnology to develop multi-drug inhibitors for cancer therapy. J Nanomed Nanotechnol. 2013; 4(6).

Vijayan Sri Ramkumar, et al. Synthesis and characterization of silver and gold nanoparticles using aqueous extract of seaweed, Turbinaria conoides, and their antimicrofouling activity. Sci World J. 2014 (2014).

Nusser K. Highly Potent API Drug Product Development and Manufacturing. Catalent. Published October 13, 2021. Accessed August 17, 2022. https://www.catalent.com/expert-content/

development-bioavailability/highly-potent-api-drug-product-development and-manufacturing/

C. allotropes of carbon with a cylindrical nanostructure. Wikipedia.org. Published April 10, 2001. Accessed August 17, 2022. https://en.m.wikipedia.org/wiki/Carbon_nanotube


Refbacks

  • There are currently no refbacks.