Open Access Open Access  Restricted Access Subscription or Fee Access

Study of Antibacterial Activity of Cu NPs and Fluorescent C-Dots Based Nano-gel

Ananya Mishra, Aparajita Basu, Divya Maheshwari, Shruti Gupta, Shubham Saxena, Amaresh Kumar Sahoo, Sintu Kumar Samanta


Post-operative infection is a serious health problem which is considered to be one of the major causes of mortality worldwide. To address this issue, anti-bacterial gels and antibiotics have been used since ages which serve the purpose of killing of bacteria, inhibiting their growth and restricting their passage to underlying tissues. Although different kinds of gels and creams have been used for this purpose, the nano-composite based gels are found to be more effective owing to the unique size dependent properties of nanoparticles. Since most of the nanoparticles based gels presently available in market are mainly made up of silver nanoparticles, they raise the issue of toxicity. Herein, we have developed an antibacterial nano gel by using copper nanoparticles (Cu NPs) and fluorescent carbon quantum dots (C-dots) which are biocompatible and less immunogenic. The developed composite nano gel showed synergistic bactericidal activity as compared to its individual component. Therefore, the use of composite nano gel of Cu NPs and C-dots may offer huge promise of development of an effective wound care material.

Full Text:



Anielski, R., BarczyƄski, M. (1998) Postoperative wound infections.I. Population data and risk factors. Przegl Lek, 55, 101-8.

Boateng, J. S., Matthews, K. H., Stevens, H. N., Eccleston, G. M. (2008) Wound healing dressing and drug delivery system: a review. J Pharm Sci, 97, 2892-2923.

Huh, A. J., Kwon, Y. J. (2011) Nanoantibiotics: A new paradigm for treating infectious diseases using nano materials in the antibiotic resistant. J Control Release, 156, 128-45.

Batista, C. A., Larson, R.G., Kotov, N. A. (2015) Nonadditivity of nanoparticle interactions, Science. 350, 1242477.

Wang, L., Hu, C., Shao, L. (2017) The antimicrobial activity of nanoparticles: present situation and prospects for the future. Int J Nanomedicine, 12, 1227-49.

Niska, K., Zielinska, E., Radomski, M. W., Inkielewicz-Stepniak, I. (2017). Metal nanoparticles in dermatology and cosmetology: Interactions with human skin cells. Chem Biol Interact, S0009-2797, 30629-9.

Chatterjee, A. K., Chakraborty, R., Basu, T. (2014) Mechanism of antibacterial activity of copper nanoparticles. Nanotechnology, 25, 135101.

Eman, A., Rasha, A. A. (2016) Synthesis of Copper Nanoparticles with Various Sizes and Shapes: Application as a Superior Non-Enzymatic Sensor and Antibacterial Agent. Int J Electrochem Sci, 11, 4712-23.

Weerasinghe, R. R., Swanson, S. J., Okada, S. F., Garrett, M. B., Kim, S. Y., Stacey, G., Boucher, R. C., Gilroy, S., Jones, A. M. (2009) Touch induces ATP release in Arabidopsis roots that is modulated by the heterotrimeric G-protein complex. FEBS Lett, 583, 2521-26.

Milosavljevic, V., Moulick, A., Kopel, P., Adam, V., Kizek, R. (2014) Microwave preparation of carbon quantum dots with different surface modification. J of Metallomics and Nanotechnologies, 3, 16-22.


  • There are currently no refbacks.