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Phylogenomic Analysis of Human Multigene Families Using Computational Approach

Muhammad Waqas Khokhar


Evolution leads to major morphological transformations and anatomical complexity achieved by higher vertebrates. The phylogenomic analysis of human multigene families (ERBB, HCK, VAMP) was conducted to check the evolutionary history and functional significance. The colossal amount of diversified protein dataset for a wide variety of vertebrates and invertebrates was used to derive the phylogeny of highly significant and functionally diverse gene families. Phylogenetic analysis reveals the mode of evolution and conservation of three gene families residing on human chromosomes. Phylogeny advocates that the expansion of multigene families has occurred after diversification of vertebrates from urochordates and prior to fish–tetrapod split. The gene duplication events occurred after speciation of vertebrates and invertebrates. The major duplications occurred within the time window of deuterostomes–protostomes and actinopterygii–sarcopterygii split. The phylogenetic analysis of multigene families exhibits high level of conservation and evolutionary significance. Phylogenetic tree reflects chromosomal segmental duplications or small-scale duplications which occurred at different time points during chordate evolution. Lineage-specific deletion events were also detected in fish and tetrapods. The study will provide better understanding of ancestral relationship and functional behavior of human multigene families to the scientists belonging to diversified fields of biology, especially comparative and evolutionary genomics biologists.


Keywords: ERBB, HCK, VAMP, phylogenomic analysis, segmental duplications

Cite this Article

Khokhar MW. Phylogenomic analysis of human multigene families using computational approach. Research & Reviews: A Journal of Bioinformatics. 2016; 3(1): 1–8p.

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