A Comparative in silico Study of the Glucose Transporters Predicts Ubiquitination of the Transporters at the C-Terminal End

Authors

  • Arpita Devi Department of Molecular Biology and Biotechnology, Tezpur University, Tezpur-784028 India

DOI:

https://doi.org/10.37591/(rrjobi).v5i2.213

Keywords:

Glucose transporters, ubiquitination, docking, binding energy

Abstract

Glucose Transporters are a family of membrane spanning proteins that transports glucose from exterior of the cell to the interior of the cell through the plasma membrane. There are 14 glucose transporters known till now. Although the transporters belong to the same family but not all function in glucose transport. They are different from each other in primary amino acid sequence. However, there is similarity in the secondary as well as tertiary structure. In this study, we have modelled the tertiary structure of all the glucose transporters. The process of degradation of GLUTs has not been studied till now. In this study, it is predicted that GLUTs are ubiquitinated and the site for ubiquitination is conserved across all members of the family.

 

Keywords: Glucose transporters; ubiquitination; docking; binding energy

Cite this Article

Arpita Devi. A comparative in silico study of the Glucose Transporters predicts ubiquitination of the transporters at the C-terminal end. Research & Reviews: A Journal of Bioinformatics. 2018; 5(2):    15–24p.

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Published

2018-10-08

Issue

Vol. 5 No. 2 (2018)

Section

Research Article

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