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Recombinant Protein Manufacturing Using Actinomycetes as Host Cells
Abstract
Actinobacteria are highly sought-after for use as cell factories or bioreactors in the pharmaceutical, agricultural, industrial, and environmental sectors. The commercial production of these proteins as recombinants and the biochemical and structural characterization of key proteins have been made possible by the genome sequencing of numerous species of actinomycetes. In this regard, better expression vectors that may be used with actinomycetes are required. As discussed in this article, recent developments in gene expression systems, knowledge of the intracellular environment, and identification and characterization of plasmids have made it possible to create workable recombinant expression systems in actinomycetes.
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References
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