Open Access
Subscription or Fee Access
Nanotechnology: Applications in Regenerative Medicine
Abstract
Nanotechnology presently has many uses in practically every one of the fields. The introduction of nanomedicine has benefitted many research areas in pharmaceutical industries. The usage of nanoparticles in drugs has shown great results that the other drugs did not. In the development of novel medicine, nanotechnology is playing an important role. It is because few medications cannot be used due to complications such as its toxicity, this can be replaced by a nanomedicine. Nanomedicine which contains nanoparticles, has higher surface to volume ratio (aspect ratio). Nanomedicine has shown its effectiveness in both diagnostics and therapeutics. In this review article the use of nanomedicine as an effective regenerative medicine will be discussed. Tissue engineering-mimic of the natural tissues in our body, cellular therapies, artificial organ transplant will also be discussed. Few of the application s of tissue engineering is also mentioned.
Keywords
References
Dinnyes, Andras, et al. "Integration of nano-and biotechnology for beta-cell and islet transplantation in type-1 diabetes treatment." Cell proliferation 53.5 (2020): e12785.
Petersmann, Astrid, et al. "Definition, classification and diagnosis of diabetes mellitus." Experimental and Clinical Endocrinology & Diabetes 127.S 01 (2019): S1-S7.
Aguayo-Mazzucato, Cristina, and Susan Bonner-Weir. "Pancreatic β cell regeneration as a possible therapy for diabetes." Cell metabolism 27.1 (2018): 57-67.
Contera, Biotechnology. "Nanotechnology and medicine, Emerg. Top." Life Sci https://doi. org/10.1042/ETLS20200350.
Veritti, Daniele, Valentina Sarao, and Paolo Lanzetta. "A propensity-score matching comparison between 27-gauge and 25-gauge vitrectomy systems for the repair of primary rhegmatogenous retinal detachment." Journal of Ophthalmology 2019 (2019).
Constantin, Brănişteanu Daniel, Bilha Andrei, and Moraru Andreea. "Vitrectomy surgery of diabetic retinopathy complications." Romanian Journal of Ophthalmology 60.1 (2016): 31.
Deschler, Emily K., Jennifer K. Sun, and Paolo S. Silva. "Side-effects and complications of laser treatment in diabetic retinal disease." Seminars in ophthalmology. Vol. 29. No. 5-6. Taylor & Francis, 2014.
Farokhzad, Omid C., and Robert Langer. "Impact of nanotechnology on drug delivery." ACS nano 3.1 (2009): 16-20.
Chen, Guangcun, et al. "Recent advances in tracking the transplanted stem cells using near- infrared fluorescent nanoprobes: turning from the first to the second near-infrared window."Advanced Healthcare Materials 7.20 (2018): 1800497.
Garbayo, Elisa, et al. "Nanomedicine and drug delivery systems in cancer and regenerative medicine." Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology 12.5 (2020):e1637.
Bahmad, Hisham F., Robert Poppiti, and John Alexis. "Nanotherapeutic approach to treat diabetic foot ulcers using tissue-engineered nanofiber skin substitutes: a review." Diabetes & Metabolic Syndrome: Clinical Research & Reviews 15.2 (2021): 487-491.
Kim, Jong Hyun, et al. "Nanotopographical regulation of pancreatic islet-like cluster formation from human pluripotent stem cells using a gradient-pattern chip." Acta Biomaterialia 95 (2019): 337-347.
Cierpka-Kmiec, Katarzyna, Agata Wronska, and Zbigniew Kmiec. "In vitro generation of pancreatic β-cells for diabetes treatment. I. β-like cells derived from human pluripotent stem cells." Folia histochemica et cytobiologica 57.1 (2019): 1-14.
Pinzi, Luca, and Giulio Rastelli. "Molecular docking: shifting paradigms in drug discovery." International journal of molecular sciences 20.18 (2019): 4331.
Heng, L. Z., et al. "Diabetic retinopathy: pathogenesis, clinical grading, management and future developments." Diabetic Medicine 30.6 (2013): 640-650.
Shanik, Michael H., et al. "Insulin resistance and hyperinsulinemia: is hyperinsulinemia the cart or the horse?" Diabetes care 31. Supplement_2 (2008): S262-S268.
Budzinskaya, M. V., et al. "On classification of diabetic retinopathy." Vestnik Oftalmologii 135.5. Vyp. 2 (2019): 272-277.
Maleki, Hassan, et al. "Nanofiber-based systems intended for diabetes." Journal of nanobiotechnology 19.1 (2021): 1-34.
He, Qin, et al. "Mesenchymal stem cell-derived exosomal miR-146a reverses diabetic β-cell dedifferentiation." Stem cell research & therapy 12.1 (2021): 1-16.
Zhou, Qiao, and Douglas A. Melton. "Pancreas regeneration." Nature 557.7705 (2018): 351-358.
Sabek, Omaima M., et al. "Three-dimensional printed polymeric system to encapsulate human mesenchymal stem cells differentiated into islet-like insulin-producing aggregates for diabetes treatment." Journal of tissue engineering 7 (2016): 2041731416638198.
Nakashima, Tadaaki, et al. "TLR4 is a critical regulator of angiotensin II-induced vascular remodeling: the roles of extracellular SOD and NADPH oxidase." Hypertension Research 38.10 (2015): 649-655.
Barkai, Uriel, Avi Rotem, and Paul de Vos. "Survival of encapsulated islets: More than a membrane story." World journal of transplantation 6.1 (2016): 69.
Gao, Yu, et al. "Stem cell tracking with optically active nanoparticles." American Journal of Nuclear Medicine and Molecular Imaging 3.3 (2013): 232.
Wang, Yingjie, et al. "Assessing in vitro stem-cell function and tracking engraftment of stem cells in ischaemic hearts by using novel iRFP gene labelling." Journal of cellular and molecular medicine 18.9 (2014): 1889-1894.
Yamaguchi, Yoko, and Rie Igarashi. "Nanotechnology for therapy of type 2 diabetes." Nihon rinsho. Japanese Journal of Clinical Medicine 64.2 (2006): 295-300.
Naruse, Zeon, Hiroyuki Shimada, and Ryusaburo Mori. "Surgical outcomes of 27-gauge and 25- gauge vitrectomy day surgery for proliferative diabetic retinopathy." International Ophthalmology 39.9 (2019): 1973-1980.
Refbacks
- There are currently no refbacks.