Open Access Open Access  Restricted Access Subscription or Fee Access

A Review on Drug Delivery Systems Using Microfluidics

Aditya Aneppanavar, Ajay Arvind, H Manoj, Prashanth Mypadi R, Anand Jatti

Abstract


Abstract

Microfluidics is undoubtedly an influential technology that is currently revolutionizing the chemical and biological studies by replicating laboratory benchtop technology on a miniature chip-scale device. In the area of drug delivery science, microfluidics offers advantages, such as accurate dosage, ideal delivery, target-precise delivery, sustainable and controlled release, several dosing, and slight side effects. These helps bring significant assets to the drug delivery systems. Microfluidic technology has been increasingly used for fabrication of drug carriers, direct drug delivery systems, high throughput screening, and formulation and immobilization of drugs. Microfluidic devices present exclusive advantages for the development of efficient drug carrier particles, cell-free protein synthesis systems, and prompt techniques for direct drug screening. Compared to bulk methods, by efficiently controlling the geometries of the fabricated chip and the flow rates of multiphase fluids, microfluidic technology aids the generation of highly stable, uniform, monodispersed particles with higher encapsulation efficiency. In this review, the generation of appropriate drug or gene carriers including different particle types using different structures of microfluidic devices is highlighted. Moreover, this paper discusses the emergence of fabricated microfluidic cell-free protein synthesis systems for potential use at point of care as well as cell-, organ-, and human-on-a-chip models as smart, sensitive, and reproducible platforms, allowing the investigation of the effects of drugs under conditions imitating the biological system.

 

Keywords: microfluidics, drug delivery system, drug carriers, nanoparticles, emulsions

Cite this Article

Aditya Aneppanavar, Ajay Arvind, H. Manoj, Prashanth Mypadi R., Anand Jatti. A Review on Drug Delivery Systems Using Microfluidics. Research & Reviews: A Journal of Biotechnology. 2020; 10(1):


Full Text:

PDF

References


Biological Diagnosis Based on Microfluidics and Nanotechnology Navid Kashaninejad Mohammad Yaghoobi Mohammad Pourhassan Moghaddam Sajad R. Bazaz Dayong Jin and Majid E. Warkiani- Jan 2019.

A microfluidic colorimetric biosensor for rapid detection of Escherichia coli O157:H7 using gold nanoparticle aggregation and smart phone imaging Lingyan Zhenga, Gaozhe Caib, Siyuan Wanga, Ming Liaoc Yanbin Lid, Jianhan Lina- July 2018.

Biological Diagnosis Based on Microfluidics and Nanotechnology Navid Kashaninejad, Mohammad Yaghoobi, Mohammad Pourhassan-Moghaddam Sajad R. BazazDayong Jin and Majid E. Warkiani- Jan 2020.

Microfluidics Devices Manufacturing and Biomedical Applications Mekonen AA, Abebe SA and Adali T- June 2019.

Microneedles for drug delivery and monitoring T. R. R. SINGH, H. MCMILLAN, K. MOONEY, A. Z. ALKILANI and R. F.DONNELLY – 2013.

Recent advances in microfluidics for drug screening. Submitted: 23 July 2019. Accepted: 07 November 2019. Published Online: 18 November 2019 Jiahui Sun, Antony R. Warden, and Xianting Ding.

Microfluidic technologies for local drug delivery by Shabir Hassan, Yu Shrike Zhang-2019.

Microfluidics in nanoparticle drug delivery; From synthesis to pre-clinical screening Jungho Ahn, Jihoon Ko, Somin Lee, James Yu, YongTae Kim, Noo Li Jeon-2018.

Microfluidics for drug delivery systems Lucero G.Aceves-Serrano,Karen A. Ordaz-Martinez,Matias Vazquez-Pi and Hyundoo Hwang -2019.

Biosensing Drug Delivery Systems for In Vivo Applications M. Birgul Akolpoglu, Ugur Bozuyuk, Pelin Erkoc and Seda Kizilel-2019.

Digital Microfluidic Platform to Maximize Diagnostic Tests with Low Sample Volumes from Newborns and Pediatric Patients Rama S. Sista, Rainer Ng, Miriam Nuffer, Michael Basmajian, Jacob Coyne,Jennifer Elderbroom, Daniel Hull, Kathryn Kay, Maithri Krishnamurthy, Christopher Roberts,Daniel Wu, Adam D. Kennedy, Rajendra Singh, Vijay Srinivasan and Vamsee K. Pamula-2020.

MULTI USE MICROFLUIDIC BIOSENSORS FOR CONTINUAL MONITORING OF BIOMARKERS FROM MICROPHYSIOLOGICAL SYSTEMS by Farnaz Lorestani, Ali Khademhosseini and Mehmet R. Dokmeci- June 2019.

Microfluidic-integrated biosensors: Prospects for point-of-care diagnostics Suveen Kumar, Saurabh Kumar, Md. Azahar Ali, Pinki Anand, Ved Varun Agrawal, Renu John, Sagar Maji and Bansi D. Malhotra 2013.

Glucose biosensor based on open-source wireless microfluidic potentiostat Conan Mercera, Richard Bennett, Peter Ó. Conghaile, James F. Rusling, Dónal Leecha-2019.

Brigitte Stadler: Preface to Special topic: Microfluidics in Drug Delivery. Biomicrofluidics, 9, 52501(2015)

S.Haeberle, D.Hradetzky, A.Schumacher, M.Vosseler, S.Messner and R. Zengerle: Microfluidics for drug delivery. IFMBE Proc, 25(VIII).

Sangeetha N. Bhatia and Donald E.Ingber: Microfluidic organ-on-chips. Nat Biotechnol, 32, 760-773(2014).

Z.Hugh Fan and Weighing Tan: DNA nanospheres with microfuidics: A promising platform for cancer diagnosis? Nanomedicine.

Stefan Metz, Raphael Holzer and Philippe Renaud: Polymide-based Microfluidic devices - Lab-on-chip.

Roger R.Dmochowski and David R.Staskin: Advances in drug delivery: Improved bioavailability and drug effect.

Li Wang, Kailei Sun, Xiaojian Hu, Gang Li, Qinghui Jin and Zhao Jianlong: A centrifugal Microfluidic device for screening protein crystallization conditions by vapour diffusion.


Refbacks

  • There are currently no refbacks.


Copyright (c) 2020 Research & Reviews: A Journal of Biotechnology