Evaluation of Anthelmintic, Analgesic and Neuropharmacological activity of Heliotropium indicum

Abstract

The present study was performed to evaluate the anthelmintic, analgesic and neuropharmacological activity of the methanol extract from the leaves of Heliotropium indicum. Anthelmintic activity was investigated using earthworm (Pheretima posthuma) & fresh leaf juice of the plant. In anthelmintic activity test, the time of paralysis for fresh juice was range from 7 min 55 s to 26 min 55 s whereas the time ranges for standard drug albendazole was 12 min 57 sec to 58 min 23 sec. The time of death start from 24 min 43 s and end to 32 min 09 s for leaf juice and for albendazole the time of death start from 16 min 23 sec and end to 84 min 19 s respectively at different dose which indicate significant anthelmintic activity of the plant. Analgesic activity was investigated using two thermal and one chemical-induced method at the dose of 200 and 400 mg/kg body weight in Swiss albino mice. In analgesic activity test, the latency time of thermal threshold was prolonged in hot plate and tail immersion tests, whereas it was inhibited by acetic acid-induced writhing test. Thus the extract of the Heliotropium indicum leaves showed moderate analgesic activity. Neuropharmacological activity was observed by open field, hole cross and dark/light box test at the dose of 200 mg/kg & 400 mg/kg body weight in Swiss albino mice. The extract significantly decrease the locomotor activity as shown by the results of open field & hole cross test which indicate significant antidepressant activity. The results also showed similar activity in light/dark box test.

Keywords: Heliotropium indicum, Anthelmintic, Analgesic, Neuropharmacological activity, Swiss albino mice.

Cite this Article

Safiur Rahman, Most Nazma Parvin, Sadia Afreen Chowdhury. Evaluation of Anthelmintic, Analgesic and Neuropharmacological Activity of Heliotropium indicum. Research & Reviews: A Journal of Biotechnology. 2019; 9(1): 31–38p.