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A Nascent Step towards the Discovery of New Generation Non-Steroidal Anti-inflammatory Agents (NSAIDs): Induced-Fit Molecular Docking and Pharmacokinetic Prediction Studies of Some Chromene Derivatives as Potential Cyclooxygenase-2 (COX-2) and Lipoxygenase (LOX) Inhibitors

Tomy Muringayil Joseph, Debarshi Kar Mahapatra

Abstract


The current computational research profoundly focuses on the comprehensive based exploration of the anti-inflammatory potential of some novel chromene derivatives against major anti-inflammatory mediators by the utilization of the induced-fit docking (IFD) method of Schrodinger software along with pharmacokinetic profile exploration. The study will positively open new pharmacodynamic applications and avenues as anti-inflammatory agents in the future.

 

Keywords: Anti-inflammatory, chromene, COX-2, docking, LOX, pharmacokinetics

Cite this Article

Tomy Muringayil Joseph, Debarshi Kar Mahapatra. A Nascent Step towards the Discovery of New Generation Non-Steroidal Anti-inflammatory Agents (NSAIDs): Induced-Fit Molecular Docking and Pharmacokinetic Prediction Studies of Some Chromene Derivatives as Potential Cyclooxygenase-2 (COX-2) and Lipoxygenase (LOX) Inhibitors. Research & Reviews: A Journal of Bioinformatics. 2018; 5(2): 30–36p.


Keywords


Chromene, Docking, Anti-inflammatory, COX-2, LOX, Pharmacokinetics

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References


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