Docking Studies on Some Benzimidazole and Triazole Analogues as Antihypertensive Agents

Abstract

The incidence rate of hypertension continues a phenomenal rise and so, there is a growing need to identify novel therapeutic agents with improved efficacy and reduced side effects. In these circumstances, drugs acting on multiple targets could offer superior efficacy profiles compared with single target drugs. Some molecules have been designed using rational drug design approach and evaluated by performing docking studies. Targets used were an angiotensin-converting enzyme, angiotensin receptor, aldosterone receptor, rennin enzyme, beta receptors (b1/b2). Surflex-docking studies were performed on a series of substituted benzimidazole fused triazole ring as an antihypertensive activity. Docking studies revealed that the nitro group, fluoro group on benzimidazole, and nitro group of triazole were significant for binding to all receptors, and some essential substituted group were also identified. Designed compounds were found to have a binding affinity with multiple targets.

Keywords: Antihypertensive agents, benzimidazole, docking studies, triazole

Cite this Article

Mishra Deepti, Vengurlekar Sudha, Chaturvedi S.C. Docking Studies on Some Benzimidazole and Triazole Analogues as Antihypertensive Agents. Research & Reviews: A Journal of Bioinformatics. 2018; 5(2): 37–39p.